病毒学
The primary end point was the percentage of patients who experienced virologic failure.
主要 终点则为出现病毒失败患者的百分率。
When a person sustains a virologic response after completing treatment, this suggests that HCV infection has been cured.
当受试者完成治疗后病毒学应答仍在持续,说明丙型肝炎病毒感染已获治愈。
The best indicators of sustained virologic response are low pre-treatment serum HBV DNA titers and elevated alanine aminotransferase (ALT) levels.
持续性病毒学应答的最佳指标是较低的治疗前血清hbv DNA滴度和较高的谷丙转氨酶(ALT)水平。
After 240 weeks of therapy, the cumulative rates of HBV polymerase mutations, virologic resistance, and clinical resistance were 29%, 20%, and 11%, respectively.
经过240周的治疗后,HBV聚合酶的蓄聚率、病毒的耐药率和临床耐药率分别是29%,20%和11%。
A careful assessment for causes of virologic failure is necessary before regimen change and all issues should be addressed to decrease risk of a second treatment failure.
更改治疗前,必须严格仔细评估病毒学失败的原因,把所有可能的不利因素降到最低,避免二线治疗失败。